MCU-INDEPENDENT CA2+ UPTAKE MEDIATES MITOCHONDRIAL CA2+ OVERLOAD AND NECROTIC CELL DEATH IN A MOUSE MODEL OF DUCHENNE MUSCULAR DYSTROPHY

MCU-independent Ca2+ uptake mediates mitochondrial Ca2+ overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy

Abstract Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major contributor to several human diseases.Indeed, Duchenne muscular dystrophy (MD) is driven by dysfunctional Ca2+ influx across the sarcolemma that causes mitochondrial Ca2+ overload, organelle rupture, and muscle necrosis.The mitochondrial Ca2+ uniporter (MCU)

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